Betaglycan: A multifunctional accessory

Betaglycan is a co-receptor for the TGFβ superfamily, particularly important in establishing the potency of its ligands on their target cells. In recent years, new insights have been gained into the structure and function of betaglycan, expanding its role from that of a simple co-receptor to include...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2011-06, Vol.339 (1-2), p.180-189
Main Authors: Bilandzic, Maree, Stenvers, Kaye L.
Format: Article
Language:English
Subjects:
Accessories
Adrenal Glands - metabolism
Adrenal Glands - physiopathology
Animals
Betaglycan
Cancer
Determinants
Endocrinology
Gonads - metabolism
Gonads - physiopathology
Humans
Inhibin
Inhibins - metabolism
Ligands
Molecular structure
neoplasms
Pathways
Pituitary Gland - metabolism
Pituitary Gland - physiopathology
Protein Structure, Tertiary
Protein Transport
Proteoglycans - chemistry
Proteoglycans - metabolism
Receptors
Receptors, Transforming Growth Factor beta - chemistry
Receptors, Transforming Growth Factor beta - metabolism
Signal Transduction
TGFβ receptor III
transforming growth factor beta
Transforming Growth Factor beta - metabolism
Tumor Suppressor Proteins - chemistry
Tumor Suppressor Proteins - metabolism
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Summary:Betaglycan is a co-receptor for the TGFβ superfamily, particularly important in establishing the potency of its ligands on their target cells. In recent years, new insights have been gained into the structure and function of betaglycan, expanding its role from that of a simple co-receptor to include additional ligand-dependent and ligand-independent roles. This review focuses on recent advances in the betaglycan field, with a particular emphasis on its newly discovered actions in mediating the trafficking of TGFβ superfamily receptors and as a determinant of the functional output of TGFβ superfamily signalling. In addition, this review encompasses a discussion of the emerging roles of the betaglycan/inhibin pathway in reproductive cancers and disease.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2011.04.014