Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride

The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spect...

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Bibliographic Details
Published in:Applied clay science 2011-06, Vol.52 (4), p.364-367
Main Authors: Kevadiya, Bhavesh D., Joshi, Ghanshyam V., Mody, Haresh M., Bajaj, Hari C.
Format: Article
Language:English
Subjects:
Carriers
Controlled release
Drugs
Earth sciences
Earth, ocean, space
Electrokinetics
Exact sciences and technology
Hydrochlorides
Hydrogel composite
Hydrogels
Intercalation
Intercalation compounds
Lidocaine hydrochloride
Mineralogy
Montmorillonite
Silicates
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Summary:The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent. ► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ► In vitro Lidocaine release from hydrogel composites.
ISSN:0169-1317
1872-9053
DOI:10.1016/j.clay.2011.03.017