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Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride
The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spect...
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| Published in: | Applied clay science 2011-06, Vol.52 (4), p.364-367 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c395t-d11d5a2e7613f276af755b419b62098f51419149850822b67663c8710707e7ae3 |
| container_end_page | 367 |
| container_issue | 4 |
| container_start_page | 364 |
| container_title | Applied clay science |
| container_volume | 52 |
| creator | Kevadiya, Bhavesh D. Joshi, Ghanshyam V. Mody, Haresh M. Bajaj, Hari C. |
| description | The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The
in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ►
In vitro Lidocaine release from hydrogel composites. |
| doi_str_mv | 10.1016/j.clay.2011.03.017 |
| format | article |
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in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ►
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in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ►
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in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ►
In vitro Lidocaine release from hydrogel composites.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><doi>10.1016/j.clay.2011.03.017</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-1317 |
| ispartof | Applied clay science, 2011-06, Vol.52 (4), p.364-367 |
| issn | 0169-1317 1872-9053 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_896238861 |
| source | ScienceDirect Freedom Collection |
| subjects | Carriers Controlled release Drugs Earth sciences Earth, ocean, space Electrokinetics Exact sciences and technology Hydrochlorides Hydrogel composite Hydrogels Intercalation Intercalation compounds Lidocaine hydrochloride Mineralogy Montmorillonite Silicates |
| title | Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride |
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