An overview of biomarkers for the ovarian cancer diagnosis

Abstract Even though there are a lot of options in treating gynecological malignancies, ovarian cancer still remains a leading cause of death. Diagnosis at an early stage is the most important determinant of survival. Current diagnostic tools applied at clinics have had very limited success in early...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2011-10, Vol.158 (2), p.119-123
Main Authors: Zhang, Bei, Cai, Feng Feng, Zhong, Xiao Yan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarker
Biomarkers, Tumor - analysis
Early Detection of Cancer
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Metabolite
Microrna
Mutation
Obstetrics and Gynecology
Ovarian cancer
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - genetics
Proteomics
Tumors
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Summary:Abstract Even though there are a lot of options in treating gynecological malignancies, ovarian cancer still remains a leading cause of death. Diagnosis at an early stage is the most important determinant of survival. Current diagnostic tools applied at clinics have had very limited success in early detection. Discovery of new diagnostic biomarkers/panels for early diagnosis of ovarian cancer is one of the main challenges of modern medicine. With the progress of techniques in genomics and proteomics, numerous molecular biomarkers/panels were identified and showed promise for ovarian cancer diagnosis, but still need further validation. This article summarizes various types of markers investigated by different strategies/technologies for the ovarian cancer diagnosis at present, including gene-, protein-based and emerging ovarian cancer indicators (such as microRNA-, metabolite-based). Before biomarker tests are translated for routine use, more researches, such as retrospective and prospective clinical trials, are needed to evaluate the overall clinical utility of the tests.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2011.04.023