Fruit Consumption Is Associated with Lower Carotid Intima-Media Thickness and C-Reactive Protein Levels in Patients with Type 2 Diabetes Mellitus

• Published in: Journal of the American Dietetic Association 2011-10, Vol.111 (10), p.1536-1542
• Main Authors: Zhu, Yanna, PhD, Zhang, Yinghui, PhD, Ling, Wenhua, PhD, Feng, Dan, PhD, Wei, Xiaoyi, PhD, Yang, Chen, MPH, Ma, Jing, MD
• Format: Article
• Language: English
• Subjects: Aged; Analysis of Variance; Biomarkers - blood; C-Reactive Protein - metabolism; Carotid Arteries - pathology; Cohort Studies; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - pathology; Diabetic Angiopathies - blood; Diabetic Angiopathies - pathology; Dietetics; Female; Fruit; Fruits; Gastroenterology and Hepatology; Humans; Internal Medicine; Male; Middle Aged; Proteins; Tunica Intima - pathology; Tunica Media - pathology
• ISSN: 0002-8223; 2212-2672; 1878-3570; 2212-2680
• DOI: 10.1016/j.jada.2011.07.010

Abstract Preliminary evidence in support of fruit intake for the prevention of cardiovascular disease in patients with type 2 diabetes mellitus (T2DM) is still limited. The objective of this study was to evaluate the association between fruit consumption and cardiovascular risk factors such as carotid intima-media thickness (CIMT) and high-sensitive C-reactive protein (hsCRP) in patients with T2DM. In this cross-sectional study, 407 patients with T2DM were recruited from August 2007 to December 2009. Dietary assessment based on 3-day 24-hour recall interviews, hsCRP levels, and CIMT were examined. Participants were categorized into three tertiles based on fruit intake. Comparisons of the participants' clinical characteristics among the three categories were performed using either one-way analysis of variance or analysis of covariance. In patients with type 2 diabetes with CIMT ≥1 mm, the intake of fruit was lower ( P =0.001), whereas the serum hsCRP level was higher ( P