Acinetobacter baumannii infection in patients with hematologic malignancies in intensive care unit: Risk factors and impact on mortality

• Published in: Journal of critical care 2011-10, Vol.26 (5), p.460-467
• Main Authors: Turkoglu, Melda, MD, Mirza, Emel, MD, Tunçcan, Özlem Güzel, MD, Erdem, Gökmen Umut, MD, Dizbay, Murat, MD, Yağcı, Münci, MD, Aygencel, Gülbin, MD, Türköz Sucak, Gülsan, MD
• Format: Article
• Language: English
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - isolation & purification; Acinetobacter Infections - complications; Acinetobacter Infections - mortality; Adult; Critical Care; Critical Illness; Critically ill; Female; Hematologic malignancy; Hematologic Neoplasms - complications; Hematologic Neoplasms - mortality; Hospital Mortality; Hospitals; Humans; Infections; Intensive Care Units - statistics & numerical data; Male; Middle Aged; Nosocomial infections; Outcome; Prospective Studies; Respiratory distress syndrome; Retrospective Studies; Risk Factors; Stem cells; Studies; Transplants & implants; Turkey - epidemiology
• ISSN: 0883-9441; 1557-8615
• DOI: 10.1016/j.jcrc.2011.04.007

Abstract Purpose We investigated the characteristics of Acinetobacter baumannii infection in critically ill patients with hematologic malignancies. Materials and Methods The prospectively collected data of patients with hematologic malignancies admitted to a medical intensive care unit of a university hospital from 2007 through 2010 were reviewed retrospectively. Results One hundred twenty-eight patients were included in the study, among whom 35 (27%) developed 39 A baumannii infections. Pneumonia was the most common infection site of A baumannii . Presence of neutropenia, underlying hematologic malignancy, and the disease status did not affect the acquisition of the infection. Advancing age, prior exposure to aminoglycosides, central venous catheterization, and presence of nasogastric tube were the independent risk factors for the development of A baumannii infections. The mortality rate was higher in patients with A baumannii infections compared with the ones without ( P = .009). However, in multivariate analysis, low Glasgow coma scale, prior immunosuppressive treatment, neutropenia, invasive mechanical ventilation, and severe sepsis were independently associated with mortality, whereas presence of A baumannii infection was not. Conclusions Despite the high mortality rate in critically ill patients with hematologic malignancies, presence of A baumannii infection was not an independent risk factor for mortality.