Pharmaceutical cocrystals: An overview

Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particula...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2011-10, Vol.419 (1), p.1-11
Main Authors: Qiao, Ning, Li, Mingzhong, Schlindwein, Walkiria, Malek, Nazneen, Davies, Angela, Trappitt, Gary
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cocrystal characterisation
Crystal engineering
Crystallization
Drug Design
drugs
General pharmacology
Grinding cocrystallisation
Medical sciences
Molecular Structure
Pharmaceutical cocrystal
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
physicochemical properties
researchers
screening
Solubility
Solution cocrystallisation
Supramolecular synthon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies, characterisation techniques, and recent theoretical developments in cocrystal screening and mechanisms of cocrystal formations. Examples of pharmaceutical cocrystals are also summarised in this paper.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.07.037