Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron fibers

On the carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug for the use in drug delivery system. This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that...

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Bibliographic Details
Published in:International journal of pharmaceutics 2011-10, Vol.419 (1), p.240-246
Main Authors: Cai, Xiaoqing, Luan, Yuxia, Dong, Qian, Shao, Wei, Li, Zhonghao, Zhao, Zhongxi
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - administration & dosage
antineoplastic agents
Biological and medical sciences
carboxymethylcellulose
Carboxymethylcellulose Sodium - chemistry
Delayed-Action Preparations
Drug Carriers - chemistry
Drug Delivery Systems
Drug release
Drug Stability
Fluorouracil - administration & dosage
General pharmacology
hydrophilicity
Hydrophobic and Hydrophilic Interactions
Kinetics
Medical sciences
Models, Theoretical
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymer fiber
polymers
sodium
Sodium carboxymethylcellulose
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Summary:On the carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug for the use in drug delivery system. This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger–Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.07.008