Tandem Cyclization–Michael Reaction by Combination of Metal- and Organocatalysis

The use of a catalytic amount of platinum complexes (1 mol %) was found to be compatible with different organocatalysts (DABCO or the Jørgensen–Hayashi catalyst) that were used in the functionalization of various activated methylenes. By this method, a series of lactones with C-3 quaternary centers...

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Bibliographic Details
Published in:Journal of organic chemistry 2011-09, Vol.76 (17), p.7287-7293
Main Authors: Alemán, José, del Solar, Virginia, Martín-Santos, Cecilia, Cubo, Leticia, Ranninger, Carmen Navarro
Format: Article
Language:English
Subjects:
Catalysis
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:The use of a catalytic amount of platinum complexes (1 mol %) was found to be compatible with different organocatalysts (DABCO or the Jørgensen–Hayashi catalyst) that were used in the functionalization of various activated methylenes. By this method, a series of lactones with C-3 quaternary centers and substitution at C-5 were prepared.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo2013077