Study on Blood Biochemical Diagnostic Indices for Hepatic Function Biomarkers in Endemic Skeletal Fluorosis

The aim of the study was to determine the relationship of fluoride in drinking water to liver function in individuals living in normal and seven endemic fluorosis areas of Punjab, India. The concentration of fluoride in drinking water of different areas varied from 5.9 to 24.5 mg/L. Study group cons...

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Bibliographic Details
Published in:Biological trace element research 2011-11, Vol.143 (2), p.803-814
Main Authors: Shashi, Aggarwal, Bhardwaj, Monika
Format: Article
Language:English
Subjects:
Acid phosphatase
Adult
Age
Alanine
alanine transaminase
Alanine Transaminase - blood
Alkaline phosphatase
Alkaline Phosphatase - blood
AMP
analysis of variance
Aspartate Aminotransferases - blood
aspartate transaminase
Biochemistry
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biotechnology
Blood
blood serum
Bone diseases
Case-Control Studies
catalytic activity
Cyclic AMP
Cyclic AMP - metabolism
Data processing
Diagnostics
Drinking water
Drinking Water - analysis
Enzymes
equations
Female
Fluoride
Fluorides
Fluorides - analysis
Fluorides - blood
Fluorosis
Fluorosis, Dental - blood
Fluorosis, Dental - metabolism
Humans
Intoxication
Life Sciences
linear models
Liver
liver function
Liver Function Tests
Male
Mathematical models
Middle Aged
Nutrition
Oncology
Osteoblasts
patients
poisoning
Skeletal system
transaminase
variance
Variance analysis
Young Adult
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Summary:The aim of the study was to determine the relationship of fluoride in drinking water to liver function in individuals living in normal and seven endemic fluorosis areas of Punjab, India. The concentration of fluoride in drinking water of different areas varied from 5.9 to 24.5 mg/L. Study group consisted of 705 patients in the age group between 20 and 60 years (mean age of 39.35 ± 11.27) affected with osteodental fluorosis were compared with 300 age- and sex-matched controls (with mean age of 35.28 ± 8.25 years). Biochemical data was analyzed by one-way analysis of variance (ANOVA) with post hoc Tukey–Kramer and Bonferroni multiple comparison tests. The relationship between hepatic enzymes was calculated by Pearson’s correlation and linear regression. The results revealed significantly (P 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-010-8944-2