Recent advances in optical imaging for cervical cancer detection

Cervical cancer is one of the most common and lethal gynecological malignancies in both developing and developed countries, and therefore, there is a considerable interest in early diagnosis and treatment of precancerous lesions. Although the current standard care mainly based on cytology and colpos...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2011-11, Vol.284 (5), p.1197-1208
Main Authors: Orfanoudaki, Irene M., Kappou, Dimitra, Sifakis, Stavros
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Cervical cancer
Contrast Media
Diagnostic Imaging - instrumentation
Diagnostic Imaging - methods
Early Detection of Cancer - instrumentation
Early Detection of Cancer - methods
Endocrinology
Female
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Industrialized nations
Medical screening
Medicine
Medicine & Public Health
Microscopy, Confocal - instrumentation
Microscopy, Confocal - methods
Obstetrics/Perinatology/Midwifery
Sensitivity and Specificity
Uterine Cervical Neoplasms - diagnosis
Vaginal Smears
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Summary:Cervical cancer is one of the most common and lethal gynecological malignancies in both developing and developed countries, and therefore, there is a considerable interest in early diagnosis and treatment of precancerous lesions. Although the current standard care mainly based on cytology and colposcopy has reduced rates of cervical cancer morbidity and mortality, many lesions are still missed or overcalled and referred for unnecessary biopsies. Optical imaging technologies, spectroscopy approaches and high-resolution imaging methods are anticipated to improve the conventional cervical cancer screening providing in vivo diagnosis with high sensitivity and specificity. Their concept is that morphologic and biochemical properties of the cervical tissue are altered in response to its malignant transformation. In addition, contrast agents that target against specific neoplastic biomarkers can enhance the effectiveness of this new technology. Due to the unprecedented growth of these optical techniques accompanied probably by favorable cost-effectiveness, the primary detection of premalignant lesions may become more accessible in both the developing and the developed countries and can offer see-to-treat workflows and early therapeutic interventions.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-2009-4