Cardiac 64-Multislice Computed Tomography Reveals Increased Epicardial Fat Volume in Patients With Acute Coronary Syndrome

• Published in: The American journal of cardiology 2011-10, Vol.108 (8), p.1119-1123
• Main Authors: Harada, Ken, MD, PhD, Amano, Tetsuya, MD, PhD, Uetani, Tadayuki, MD, PhD, Tokuda, Yoshiyuki, MD, PhD, Kitagawa, Katsuhide, MD, Shimbo, Yusaku, MD, Kunimura, Ayako, MD, Kumagai, Soichiro, MD, Yoshida, Tomohiro, MD, Kato, Bunichi, MD, PhD, Kato, Masataka, MD, Marui, Nobuyuki, MD, PhD, Ishii, Hideki, MD, PhD, Matsubara, Tatsuaki, MD, PhD, Murohara, Toyoaki, MD, PhD
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - diagnostic imaging; Acute Coronary Syndrome - etiology; Acute coronary syndromes; Adipose Tissue - diagnostic imaging; Adiposity; Aged; Atherosclerosis; Atherosclerosis - complications; Atherosclerosis - diagnostic imaging; Biological and medical sciences; Body Mass Index; Cardiology. Vascular system; Cardiovascular; Coronary heart disease; Cytokines; Disease Progression; Female; Follow-Up Studies; Heart; Heart attacks; Humans; Male; Medical sciences; Middle Aged; Myocarditis. Cardiomyopathies; Pericardium - diagnostic imaging; Prognosis; Regression analysis; Retrospective Studies; Risk Factors; Sensitivity and Specificity; Tomography; Tomography, X-Ray Computed - methods
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2011.06.012

Inflammatory cytokines released from epicardial fat around coronary arteries may modulate the coronary arteries and promote coronary atherosclerosis. We assessed the hypothesis that epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS). EFV was measured in 80 Japanese patients hospitalized for ACS using 64-multislice computed tomography. The ACS group included 51 patients with ST-segment elevated myocardial infarction and 29 patients with non–ST-segment elevated myocardial infarction. All patients underwent emergency coronary angioplasty and 64-multislice computed tomographic scanning during hospitalization. The control group included 90 consecutive outpatients with suspected ACS whose coronary computed tomographic results were normal. EFV was larger in patients with ACS than in the control group (117 ± 47 vs 95 ± 33 ml, p 100 ml was independently associated with ACS (odds ratio 2.84, 95% confidence interval 1.17 to 6.87, p = 0.021). Receiver operator characteristic analysis determined a cut-off value of 100.3 ml with a sensitivity of 75% and a specificity of 60% for ACS (area under the curve 0.692, 95% confidence interval 0.596 to 0.777, p