Thyroid hormone levels predict the change in body weight: a prospective study

Eur J Clin Invest 2011; 41 (11): 1202–1209 Background  Different studies, mostly cross‐sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim of this study was to determine the association between thyroid func...

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Published in:European journal of clinical investigation 2011-11, Vol.41 (11), p.1202-1209
Main Authors: Soriguer, Federico, Valdes, Sergio, Morcillo, Sonsoles, Esteva, Isabel, Almaraz, Maria C., de Adana, Maria S. R., Tapia, Maria J., Dominguez, Marta, Gutierrez-Repiso, Carolina, Rubio-Martin, Elehazara, Garrido-Sanchez, Lourdes, Perez, Vidal, Garriga, Maria J., Rojo-Martinez, Gemma, Garcia-Fuentes, Eduardo
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Adult
Biological and medical sciences
Body Weight
Cohort Studies
Female
Follow-Up Studies
General aspects
Humans
insulin resistance
Insulin Resistance - physiology
Iodine - urine
leptin
Leptin - blood
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - blood
Prospective Studies
thyroid hormone
Thyroid Hormones - blood
Thyrotropin - blood
Triiodothyronine - blood
Weight Gain - physiology
Weight Loss - physiology
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Summary:Eur J Clin Invest 2011; 41 (11): 1202–1209 Background  Different studies, mostly cross‐sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim of this study was to determine the association between thyroid function and the risk for obesity. Materials and methods  In this population‐based prospective study, measurements were made of anthropometric parameters, thyroid hormone function and urinary iodine in a cohort of the Pizarra Study (n = 937), and repeated 6 years later (n = 784). At the second point, measurements were also made of leptin and adiponectin. Results  Among the persons who were not obese at the start of the study, the odds ratio (OR) of becoming obese for those in the fourth quartile (Q4) for free triiodothyronine (FT3) (versus those in Q1) was 2·94 (1·46–5·90) (P = 0·005). The OR of becoming obese in persons in Q4 of FT4 (versus those in Q1) was 3·06 (1·23–7·43) (P = 0·01). Those persons in Q4 of weight gain had a higher FT3 at the 6‐year follow‐up than those whose weight gain was in Q1 (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2011.02526.x