Methods for the Preparation of Allenes Employing Indium- and Zinc-Mediated Dehalogenation Reactions in Aqueous Solutions

Simple and mild methods for the synthesis of allenes, employing indium- and zinc-mediated dehalogenation reactions of vicinal dihalides in an aqueous solvent, are described. By using these procedures, various allenylmethyl aryl ethers and monosubstituted allenes have been prepared in good to excelle...

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Bibliographic Details
Published in:Journal of organic chemistry 2011-10, Vol.76 (20), p.8518-8523
Main Authors: Lin, Mei-Huey, Tsai, Wen-Shing, Lin, Long-Zhi, Hung, Shiang-Fu, Chuang, Tsung-Hsun, Su, Yi-Jen
Format: Article
Language:English
Subjects:
Aliphatic compounds
Alkadienes - chemical synthesis
Alkadienes - pharmacology
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Catalysis
Chemistry
Chemistry, Pharmaceutical - methods
Ethers - chemical synthesis
Ethers - pharmacology
Exact sciences and technology
Green Chemistry Technology
Halogens - chemistry
Humans
Indium - chemistry
Molecular Structure
Neoplasms - drug therapy
Organic chemistry
Preparations and properties
Solutions
Stereoisomerism
Water
Zinc - chemistry
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Summary:Simple and mild methods for the synthesis of allenes, employing indium- and zinc-mediated dehalogenation reactions of vicinal dihalides in an aqueous solvent, are described. By using these procedures, various allenylmethyl aryl ethers and monosubstituted allenes have been prepared in good to excellent yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo2015104