Real-time handheld optical-resolution photoacoustic microscopy

In this paper a new generation of optical-resolution photoacoustic microscopy (OR-PAM) with a wide range of potential clinical applications is demonstrated. Using fast scanning mirrors, an image guide with 30,000 fiber pixels, a refocusing lens and a unique probe we managed to reduce the footprint o...

Full description

Saved in:
Bibliographic Details
Published in:Optics express 2011-10, Vol.19 (21), p.20097-20102
Main Authors: Hajireza, Parsin, Shi, Wei, Zemp, Roger J
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - pathology
Dermatology - methods
Diagnostic Imaging - methods
Equipment Design
Hair - pathology
Humans
Lasers
Lenses
Mice
Microscopy, Acoustic - methods
Microscopy, Electron, Scanning - methods
Normal Distribution
Optics and Photonics
Phantoms, Imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this paper a new generation of optical-resolution photoacoustic microscopy (OR-PAM) with a wide range of potential clinical applications is demonstrated. Using fast scanning mirrors, an image guide with 30,000 fiber pixels, a refocusing lens and a unique probe we managed to reduce the footprint of an OR-PAM system from a stationary table-top system to a portable, 4 cm by 6 cm, probe weighing ~500 g tethered to a scanning unit. The phantom studies show that the handheld optical-resolution photoacoustic microscope is able to image with ~7 μm resolution. For in vivo studies images of the microvasculature in a Swiss Webster mouse ear are shown. The compact, flexible nature of the proposed design and the small footprint of the apparatus increase the usability of OR-PAM for potential clinical applications such as in dermatology.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.19.020097