Dual Kinetically Controlled Native Chemical Ligation Using a Combination of Sulfanylproline and Sulfanylethylanilide Peptide

Dual kinetically controlled native chemical ligation using a newly developed sulfanylproline-mediated reaction in combination with an N-sulfanylethylanilide peptide was successfully applied to a previously unreported sequential coupling of peptide fragments added simultaneously to the reaction.

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Bibliographic Details
Published in:Organic letters 2011-10, Vol.13 (20), p.5588-5591
Main Authors: Ding, Hao, Shigenaga, Akira, Sato, Kohei, Morishita, Ko, Otaka, Akira
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Kinetics
Molecular Structure
Neuropeptides - chemical synthesis
Neuropeptides - chemistry
Peptides - chemical synthesis
Peptides - chemistry
Stereoisomerism
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
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Description
Summary:Dual kinetically controlled native chemical ligation using a newly developed sulfanylproline-mediated reaction in combination with an N-sulfanylethylanilide peptide was successfully applied to a previously unreported sequential coupling of peptide fragments added simultaneously to the reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202316v