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Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE
BTB/POZ protein family plays a key role in many biological processes by regulating the transcriptional activities of some downstream genes. Here, we characterized the member of C 2 H 2 type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1). The complete sequence of ZBTB1 cDNA contain...
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| Published in: | Molecular and cellular biochemistry 2011-11, Vol.357 (1-2), p.405-414 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c542t-5c73ee7f2e368026159bfbf419abc1033e1c67b222091cde7c7672158f760d83 |
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| cites | cdi_FETCH-LOGICAL-c542t-5c73ee7f2e368026159bfbf419abc1033e1c67b222091cde7c7672158f760d83 |
| container_end_page | 414 |
| container_issue | 1-2 |
| container_start_page | 405 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 357 |
| creator | Liu, Qingmei Yao, Feng Wang, Minghua Zhou, Bin Cheng, Hongxia Wang, Weiping Jin, Li Lin, Qiang Wang, Jiu-Cun |
| description | BTB/POZ protein family plays a key role in many biological processes by regulating the transcriptional activities of some downstream genes. Here, we characterized the member of C
2
H
2
type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1). The complete sequence of ZBTB1 cDNA contains a 2142 bp open reading frame (ORF) and encodes a 713 amino acid protein with an N-terminal BTB/POZ domain that is similar to the same domain of other known transcription regulators and eight classical zinc finger C
2
H
2
motifs in the C-terminus. Subcellular localization analysis demonstrated that ZBTB1 was localized to the nucleus, forming dot-like structures. Transcriptional activity assays showed that ZBTB1 was a transcription repressor and overexpression of ZBTB1 in the COS7 cells reduced the transcriptional activities of cAMP response element (CRE). Further studies showed that the BTB domain and ZNF motifs of ZBTB1 may both be involved in this suppression. These results suggest that ZBTB1 protein may act as a transcription repressor in the activation of CREB and cAMP-mediated signal transduction pathways to mediate cellular functions. |
| doi_str_mv | 10.1007/s11010-011-0911-5 |
| format | article |
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2
H
2
type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1). The complete sequence of ZBTB1 cDNA contains a 2142 bp open reading frame (ORF) and encodes a 713 amino acid protein with an N-terminal BTB/POZ domain that is similar to the same domain of other known transcription regulators and eight classical zinc finger C
2
H
2
motifs in the C-terminus. Subcellular localization analysis demonstrated that ZBTB1 was localized to the nucleus, forming dot-like structures. Transcriptional activity assays showed that ZBTB1 was a transcription repressor and overexpression of ZBTB1 in the COS7 cells reduced the transcriptional activities of cAMP response element (CRE). Further studies showed that the BTB domain and ZNF motifs of ZBTB1 may both be involved in this suppression. These results suggest that ZBTB1 protein may act as a transcription repressor in the activation of CREB and cAMP-mediated signal transduction pathways to mediate cellular functions.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-011-0911-5</identifier><identifier>PMID: 21706167</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Biochemistry ; Biological activity ; Biology ; Biomedical and Life Sciences ; C-Terminus ; Cardiology ; Cell Nucleus - metabolism ; Cellular signal transduction ; Cloning, Molecular ; COS Cells ; Cyclic adenylic acid ; Cyclic AMP response element-binding protein ; Cyclic AMP Response Element-Binding Protein - genetics ; Cyclic AMP Response Element-Binding Protein - metabolism ; DNA binding proteins ; Ethylenediaminetetraacetic acid ; Gene Expression Regulation ; Genes ; Genetic aspects ; Genetic transcription ; HeLa Cells ; Humans ; Life Sciences ; Localization ; Medical Biochemistry ; Molecular Sequence Data ; Oncology ; Open reading frames ; Protein Structure, Tertiary - genetics ; Proteins ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Response Elements ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Signal Transduction ; Transcription ; Transcription activation ; Transcription, Genetic ; Zinc ; Zinc finger proteins ; Zinc Fingers - genetics</subject><ispartof>Molecular and cellular biochemistry, 2011-11, Vol.357 (1-2), p.405-414</ispartof><rights>Springer Science+Business Media, LLC. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer Science+Business Media, LLC. 2011.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-5c73ee7f2e368026159bfbf419abc1033e1c67b222091cde7c7672158f760d83</citedby><cites>FETCH-LOGICAL-c542t-5c73ee7f2e368026159bfbf419abc1033e1c67b222091cde7c7672158f760d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21706167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Qingmei</creatorcontrib><creatorcontrib>Yao, Feng</creatorcontrib><creatorcontrib>Wang, Minghua</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Cheng, Hongxia</creatorcontrib><creatorcontrib>Wang, Weiping</creatorcontrib><creatorcontrib>Jin, Li</creatorcontrib><creatorcontrib>Lin, Qiang</creatorcontrib><creatorcontrib>Wang, Jiu-Cun</creatorcontrib><title>Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>BTB/POZ protein family plays a key role in many biological processes by regulating the transcriptional activities of some downstream genes. Here, we characterized the member of C
2
H
2
type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1). The complete sequence of ZBTB1 cDNA contains a 2142 bp open reading frame (ORF) and encodes a 713 amino acid protein with an N-terminal BTB/POZ domain that is similar to the same domain of other known transcription regulators and eight classical zinc finger C
2
H
2
motifs in the C-terminus. Subcellular localization analysis demonstrated that ZBTB1 was localized to the nucleus, forming dot-like structures. Transcriptional activity assays showed that ZBTB1 was a transcription repressor and overexpression of ZBTB1 in the COS7 cells reduced the transcriptional activities of cAMP response element (CRE). Further studies showed that the BTB domain and ZNF motifs of ZBTB1 may both be involved in this suppression. These results suggest that ZBTB1 protein may act as a transcription repressor in the activation of CREB and cAMP-mediated signal transduction pathways to mediate cellular functions.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>C-Terminus</subject><subject>Cardiology</subject><subject>Cell Nucleus - metabolism</subject><subject>Cellular signal transduction</subject><subject>Cloning, Molecular</subject><subject>COS Cells</subject><subject>Cyclic adenylic acid</subject><subject>Cyclic AMP response element-binding protein</subject><subject>Cyclic AMP Response Element-Binding Protein - genetics</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>DNA binding proteins</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic transcription</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Localization</subject><subject>Medical Biochemistry</subject><subject>Molecular Sequence Data</subject><subject>Oncology</subject><subject>Open reading frames</subject><subject>Protein Structure, Tertiary - genetics</subject><subject>Proteins</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Response Elements</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction</subject><subject>Transcription</subject><subject>Transcription activation</subject><subject>Transcription, Genetic</subject><subject>Zinc</subject><subject>Zinc finger proteins</subject><subject>Zinc Fingers - genetics</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNkl1rFDEUhoModq3-AG8k2Auvps1JJsnMZbvUDyhWZK96EzKZpM0yk6yT2YL-es86VUEoSEJOSJ73cL4IeQ3sFBjTZwWAAasYQMVaPOQTsgKpRVW30D4lKyYYqxrQ-oi8KGXLEEb2OTnioJkCpVdk-znf-4He7Ueb6MXm4uzL9Q3t82hjqlxOM9qYbumPmBwNePMT3U159jHRG8SBxnQXuzgXOk82FTfF3RxzsgO1bo73cY6-0Bzo-uvlS_Is2KH4Vw_2mGzeX27WH6ur6w-f1udXlZM1nyvptPBeB-6FahhXINsudKGG1nYOmBAenNId5xxzdr3XTivNQTZBK9Y34pi8W9xinN_2vsxmjMX5YbDJ530xTdtI1tSsRvLtP-Q27yeM_RfEgdWgEDp5DOKqrTVuKZA6XahbO3gTU8hYDoer92PEOvoQ8f1cA3pUWvD_FQjZchBMSBTAInBTLmXyweymONrpuwFmDtNglmkw2GFzmAZz0Lx5iH3fjb7_o_jdfgT4AhT8OjT3b3KPe_0JQBK8JA</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Liu, Qingmei</creator><creator>Yao, Feng</creator><creator>Wang, Minghua</creator><creator>Zhou, Bin</creator><creator>Cheng, Hongxia</creator><creator>Wang, Weiping</creator><creator>Jin, Li</creator><creator>Lin, Qiang</creator><creator>Wang, Jiu-Cun</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE</title><author>Liu, Qingmei ; Yao, Feng ; Wang, Minghua ; Zhou, Bin ; Cheng, Hongxia ; Wang, Weiping ; Jin, Li ; Lin, Qiang ; Wang, Jiu-Cun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-5c73ee7f2e368026159bfbf419abc1033e1c67b222091cde7c7672158f760d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biochemistry</topic><topic>Biological activity</topic><topic>Biology</topic><topic>Biomedical and Life Sciences</topic><topic>C-Terminus</topic><topic>Cardiology</topic><topic>Cell Nucleus - metabolism</topic><topic>Cellular signal transduction</topic><topic>Cloning, Molecular</topic><topic>COS Cells</topic><topic>Cyclic adenylic acid</topic><topic>Cyclic AMP response element-binding protein</topic><topic>Cyclic AMP Response Element-Binding Protein - genetics</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>DNA binding proteins</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic transcription</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Localization</topic><topic>Medical Biochemistry</topic><topic>Molecular Sequence Data</topic><topic>Oncology</topic><topic>Open reading frames</topic><topic>Protein Structure, Tertiary - genetics</topic><topic>Proteins</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Response Elements</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction</topic><topic>Transcription</topic><topic>Transcription activation</topic><topic>Transcription, Genetic</topic><topic>Zinc</topic><topic>Zinc finger proteins</topic><topic>Zinc Fingers - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qingmei</creatorcontrib><creatorcontrib>Yao, Feng</creatorcontrib><creatorcontrib>Wang, Minghua</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Cheng, Hongxia</creatorcontrib><creatorcontrib>Wang, Weiping</creatorcontrib><creatorcontrib>Jin, Li</creatorcontrib><creatorcontrib>Lin, Qiang</creatorcontrib><creatorcontrib>Wang, Jiu-Cun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Journals (ProQuest Database)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qingmei</au><au>Yao, Feng</au><au>Wang, Minghua</au><au>Zhou, Bin</au><au>Cheng, Hongxia</au><au>Wang, Weiping</au><au>Jin, Li</au><au>Lin, Qiang</au><au>Wang, Jiu-Cun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>357</volume><issue>1-2</issue><spage>405</spage><epage>414</epage><pages>405-414</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>BTB/POZ protein family plays a key role in many biological processes by regulating the transcriptional activities of some downstream genes. Here, we characterized the member of C
2
H
2
type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1). The complete sequence of ZBTB1 cDNA contains a 2142 bp open reading frame (ORF) and encodes a 713 amino acid protein with an N-terminal BTB/POZ domain that is similar to the same domain of other known transcription regulators and eight classical zinc finger C
2
H
2
motifs in the C-terminus. Subcellular localization analysis demonstrated that ZBTB1 was localized to the nucleus, forming dot-like structures. Transcriptional activity assays showed that ZBTB1 was a transcription repressor and overexpression of ZBTB1 in the COS7 cells reduced the transcriptional activities of cAMP response element (CRE). Further studies showed that the BTB domain and ZNF motifs of ZBTB1 may both be involved in this suppression. These results suggest that ZBTB1 protein may act as a transcription repressor in the activation of CREB and cAMP-mediated signal transduction pathways to mediate cellular functions.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21706167</pmid><doi>10.1007/s11010-011-0911-5</doi><tpages>10</tpages></addata></record> |
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| subjects | Amino Acid Sequence Amino acids Animals Base Sequence Biochemistry Biological activity Biology Biomedical and Life Sciences C-Terminus Cardiology Cell Nucleus - metabolism Cellular signal transduction Cloning, Molecular COS Cells Cyclic adenylic acid Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism DNA binding proteins Ethylenediaminetetraacetic acid Gene Expression Regulation Genes Genetic aspects Genetic transcription HeLa Cells Humans Life Sciences Localization Medical Biochemistry Molecular Sequence Data Oncology Open reading frames Protein Structure, Tertiary - genetics Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Response Elements Sequence Analysis, DNA Sequence Homology, Amino Acid Signal Transduction Transcription Transcription activation Transcription, Genetic Zinc Zinc finger proteins Zinc Fingers - genetics |
| title | Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE |
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