Effect of different doses of GLP-2 (Teduglutide) on acute esophageal lesion due to acid-pepsin perfusion in male rats

• Published in: Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011-10, Vol.32 (10), p.2086-2090
• Main Authors: Moloudi, Rohallah, Nabavizadeh, Fatemeh, Nahrevanian, Hossein, Hassanzadeh, Gholamreza
• Format: Article
• Language: English
• Subjects: animal models; Animals; anti-inflammatory activity; Biological and medical sciences; Blood flow; Dangerous; digestive tract mucosa; Esophagus; Esophagus - drug effects; Esophagus - pathology; Fundamental and applied biological sciences. Psychology; Gastro esophageal reflux; Gastroenterology. Liver. Pancreas. Abdomen; gastroesophageal reflux; gastrointestinal system; GLP-2 (Teduglutide); Humans; Hydrochloric Acid - pharmacology; Lesions; Male; Males; Medical sciences; Metabolites; Mucous membrane; Mucous Membrane - drug effects; Mucous Membrane - pathology; Nitric oxide; Nitric Oxide - metabolism; Other diseases. Semiology; Pepsin A - pharmacology; Peptides; Peptides - pharmacology; protective effect; Random Allocation; Rats; Rats, Wistar; Vertebrates: endocrinology
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/j.peptides.2011.09.004

► Acid-pepsin perfusion by pump induced esophageal lesions in rat. ► Pre-administration of GLP-2 (Teduglutide) with acid-pepsin perfusion, significantly reduced esophageal complications and lesion size. ► The GLP-2 (Teduglutide) healing effect on esophageal lesion due to NO pathway. Gastro-esophageal reflux currently is widespread disorders with dangerous complications. GLP-2 is a peptide that has trophic and anti-inflammatory effects on gastrointestinal mucosa. The aim of this study was to evaluate the protective role of GLP-2 in esophageal mucosa lesion due to perfusion acid-pepsin. Thirty-six male rats were used in this study and divided into six groups. They were control, acid-pepsin, GLP-2 20μg, GLP-2 30μg, GLP-2 40μg and GLP-2 50μg/kg groups. Esophageal blood flow, plasma NO metabolite, esophageal tissue NO metabolites and histological study of esophagus were performed as indicators of esophageal damage following acid-pepsin perfusion. Results showed that GLP-2 significantly increased plasma and tissue NO metabolites in comparison to acid-pepsin group. Also histological study showed significantly fewer lesions in the most effective dose GLP-2 30μg in comparison to acid-pepsin group, our results show that GLP-2 could be useful for the treatment of esophageal in animal model.