Antioxidant status in cerebrovascular accident

Ischemia is associated with the pathological changes caused by the accumulation of reactive oxygen metabolites (ROM) in cerebrovascular accident (CVA). The aim of this study was to determine red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase activities and copper and zinc concentrati...

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Bibliographic Details
Published in:Biological trace element research 2001-05, Vol.80 (2), p.115-124
Main Authors: Kocatürk, P A, Akbostanci, M C, Işikay, C, Ocal, A, Tuncel, D, Kavas, G O, Mutluer, N
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidants
Antioxidants - metabolism
Case-Control Studies
Catalase - blood
Copper
Copper - blood
Enzymatic activity
Erythrocytes - metabolism
Female
Humans
Male
Medical research
Metabolites
Middle Aged
Oxidative stress
Spectral analysis
Stroke - blood
Superoxide Dismutase - blood
Time Factors
Vascular surgery
Zinc
Zinc - blood
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Summary:Ischemia is associated with the pathological changes caused by the accumulation of reactive oxygen metabolites (ROM) in cerebrovascular accident (CVA). The aim of this study was to determine red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase activities and copper and zinc concentrations both in plasma and in red cells in CVA. Cu/Zn-SOD and catalase activities of 16 patients, with an average age of 64 yr, were measured spectrophotometrically; copper and zinc concentrations were determined by atomic absorption spectrophotometer. The results showed that Cu/Zn-SOD activity was increased markedly in patients compared to the young controls and reached a peak on the d 5 of the disease, whereas the catalase activity of the patients on d 3 and d 5 were in the normal range, but higher on d 10. The enzyme activities of the elderly group were generally increased compared to the young controls. Copper and zinc concentrations showed corresponding alterations. These findings suggested that the effects of oxidative stress in CVA might be reflected in red cell and plasma parameters.
ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/BTER:80:2:115