Intensive care-acquired hypernatremia after major cardiothoracic surgery is associated with increased mortality

Purpose Hypernatremia is common in the medical Intensive Care Unit (ICU) and has been described as an independent risk factor for mortality. Hypernatremia has not yet been studied in a collection of ICU patients after cardiothoracic surgery. Therefore, we wanted to determine the incidence of hyperna...

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Bibliographic Details
Published in:Intensive care medicine 2010-10, Vol.36 (10), p.1718-1723
Main Authors: Lindner, Gregor, Funk, Georg-Christian, Lassnigg, Andrea, Mouhieddine, Mohamed, Ahmad, Salem-Ahmed, Schwarz, Christoph, Hiesmayr, Michael
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Aprotinin
Austria - epidemiology
Biological and medical sciences
Clinical death. Palliative care. Organ gift and preservation
Critical Care Medicine
Electrolytes
Emergency Medicine
Female
Health aspects
Heart surgery
Hospital Mortality
Hospital patients
Hospitals
Humans
Hypernatremia
Hypernatremia - complications
Hypernatremia - mortality
Hyponatremia
Incidence
Intensive
Intensive care
Intensive care medicine
Intensive Care Units
Length of Stay
Male
Medical research
Medical sciences
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Mortality
Original
Pain Medicine
Patients
Pediatrics
Pneumology/Respiratory System
Pulmonary arteries
Retrospective Studies
Risk factors
Sodium
Survival Analysis
Thoracic Surgery
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Summary:Purpose Hypernatremia is common in the medical Intensive Care Unit (ICU) and has been described as an independent risk factor for mortality. Hypernatremia has not yet been studied in a collection of ICU patients after cardiothoracic surgery. Therefore, we wanted to determine the incidence of hypernatremia in a surgical ICU and its association with outcomes of critically ill surgical patients. Methods In this retrospective cohort study performed at a surgical ICU of a university hospital in Vienna, patients were admitted to the ICU after major cardiothoracic surgery between May 1999 and October 2007. Data on serum sodium in the ICU, ICU mortality, hospital mortality, and length of ICU stay were collected prospectively. Results 2,699 patients underwent surgery during the study period, and 2,314 patients were included in the study. Two hundred twenty-one (10%) patients acquired hypernatremia during their ICU stay. Median onset of hypernatremia was on day 4 (2–7). Patients with ICU-acquired hypernatremia had a higher ICU mortality (19%) compared to patients without hypernatremia (8%; p  
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-010-1968-4