High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys

Objective : To examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, could increase s-IGF-I and s-IGF-I/s-IGFBP-3 in healthy, prepubertal children. IGF-I levels are positively associated with growth velocity in children and some studies suggest t...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical nutrition 2004-09, Vol.58 (9), p.1211-1216
Main Authors: Hoppe, C, Mølgaard, C, Juul, A, Michaelsen, K F
Format: Article
Language:English
Subjects:
Animals
Anthropometry
Biological and medical sciences
Boys
Child
Children
Clinical Nutrition
Deprivation
Diet
Diet Records
Dietary Proteins - administration & dosage
Energy Intake
Epidemiology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Growth - drug effects
Humans
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor Binding Protein 3 - metabolism
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-binding protein 3
Internal Medicine
Low fat
Male
Meat
Medicine
Medicine & Public Health
Metabolic Diseases
Milk
Milk - chemistry
Nutrition
original-communication
Physical growth
Proteins
Public Health
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective : To examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, could increase s-IGF-I and s-IGF-I/s-IGFBP-3 in healthy, prepubertal children. IGF-I levels are positively associated with growth velocity in children and some studies suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished children. Design : In all, 24 8-y-old boys were asked to take either 1.5 l of skimmed milk ( n =12) or the same amount of protein as 250 g low fat meat ( n =12) daily for 7 days. The remaining diet they could choose freely. At baseline and after 7 days, anthropometrical variables were measured, diet was registered (3-day weighed records), and s-IGF-I and s-IGFBP-3 (RIA) were determined after fast. Results : PI increased by 61% in the milk group to 4.0 g/kg/day ( P
ISSN:0954-3007
1476-5640
DOI:10.1038/sj.ejcn.1601948