Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Objective It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pat...

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Bibliographic Details
Published in:Cancer causes & control 2010-12, Vol.21 (12), p.2287-2293
Main Authors: Wilschut, Janneke A, Habbema, J. Dik F, Ramsey, Scott D, Boer, Rob, Looman, Caspar W. N, van Ballegooijen, Marjolein
Format: Article
Language:English
Subjects:
Abstracting
Adenoma
Adenoma - epidemiology
Adenoma - etiology
Adenoma prevalence
Adult
Age
Algorithms
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer screening
Case control studies
Colonoscopy
Colorectal cancer
colorectal neoplasms
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Disease Susceptibility - epidemiology
Epidemiology
Family Health
Family history
Family medical history
Female
Gastroenterology
Gender
Genetic disorders
Hematology
Hereditary nonpolyposis colorectal neoplasms
Humans
Male
Medical History Taking
Meta-analysis
Middle Aged
Neoplasia
Oncology
Original Paper
Prevalence
Public Health
Regression analysis
Risk Factors
Tumors
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Summary:Objective It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without. Methods We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder. Results Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups. Conclusion Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-010-9654-y