Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model

The efficacy of allicin compared with fluconazole in alleviating systemic Candida albicans infections was evaluated both in vitro and in vivo through a systemic candidiasis mouse model. Determination of in vitro minimum inhibitory concentrations (MICs) for different C. albicans isolates revealed tha...

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Bibliographic Details
Published in:FEMS microbiology letters 2011-02, Vol.315 (2), p.87-93
Main Authors: Khodavandi, Alireza, Alizadeh, Fahimeh, Harmal, Nabil S, Sidik, Shiran M, Othman, Fauziah, Sekawi, Zamberi, Jahromi, Mohammad Ali Farboodniay, Ng, Kee-Peng, Chong, Pei Pei
Format: Article
Language:English
Subjects:
allicin
Animal models
Animals
Antifungal agents
Candida albicans
Candida albicans - cytology
Candida albicans - drug effects
Candidiasis
Candidiasis - drug therapy
Candidiasis - mortality
Cell surface
Disease Models, Animal
Effectiveness
Female
Fluconazole
Fluconazole - pharmacology
Fluconazole - therapeutic use
Humans
in vitro
in vivo
In vivo methods and tests
Lysis
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Microbial Viability - drug effects
Microbiology
Microscopy, Electron, Scanning
Minimum inhibitory concentration
Mushrooms
Scanning electron microscopy
Sulfinic Acids - pharmacology
Sulfinic Acids - therapeutic use
Survival
Survival Analysis
Treatment Outcome
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Summary:The efficacy of allicin compared with fluconazole in alleviating systemic Candida albicans infections was evaluated both in vitro and in vivo through a systemic candidiasis mouse model. Determination of in vitro minimum inhibitory concentrations (MICs) for different C. albicans isolates revealed that both allicin and fluconazole showed different MICs that ranged from 0.05 to 12.5 μg mL⁻¹ and 0.25 to 16 μg mL⁻¹, respectively. A time-kill study showed a significant effect of allicin (P
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2010.02170.x