Potential of plant proteins for medical applications

Various natural and synthetic polymers are being explored to develop biomaterials for tissue engineering and drug delivery. Although proteins are preferable over carbohydrates and synthetic polymers, biomaterials developed from proteins lack the mechanical properties and/or biocompatibilities requir...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2011-10, Vol.29 (10), p.490-498
Main Authors: Reddy, Narendra, Yang, Yiqi
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
biocompatible materials
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biological and medical sciences
Biomaterials
Biomedical materials
Biopolymers - chemistry
Biopolymers - therapeutic use
Biotechnology
Carbohydrates
Collagen
Drug delivery systems
Drug Delivery Systems - methods
drugs
Fibers
Fundamental and applied biological sciences. Psychology
Gluten
Health. Pharmaceutical industry
Humans
hydrocolloids
Hydrogels
in vitro studies
Industrial applications and implications. Economical aspects
Internal Medicine
Mechanical properties
Miscellaneous
nanoparticles
Plant Proteins - chemistry
Plant Proteins - therapeutic use
Polymers
Proteins
Skin & tissue grafts
synthetic polymers
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
Triticum aestivum
Wheat
wheat gluten
wheat protein
zein
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Summary:Various natural and synthetic polymers are being explored to develop biomaterials for tissue engineering and drug delivery. Although proteins are preferable over carbohydrates and synthetic polymers, biomaterials developed from proteins lack the mechanical properties and/or biocompatibilities required for medical applications. Plant proteins are widely available, have low potential to be immunogenic and can be made into fibers, films, hydrogels and micro- and nano-particles for medical applications. Studies, mostly with zein, have demonstrated the potential of using plant proteins for tissue engineering and drug delivery. Although other plant proteins such as wheat gluten and soyproteins have also shown biocompatibility using in vitro studies, fabricating biomaterials such as nano-fibers and nano-particles from soy and wheat proteins offers considerable challenges.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2011.05.003