P11 Increased risk of fetal loss and infant death in obese women

• Published in: Journal of epidemiology and community health (1979) 2010-09, Vol.64 (Suppl 1), p.A37-A38
• Main Authors: Tennant, P W G, Rankin, J, Bell, R
• Format: Article
• Language: English
• Subjects: Births; Congenital defects; Infant mortality; Infants; Neonates; Obesity; Pregnancy
• ISSN: 0143-005X; 1470-2738
• DOI: 10.1136/jech.2010.120477.11

ObjectiveTo investigate the association between maternal obesity and the prevalence of fetal and infant death.DesignCohort study using prospectively collected data matched to a high-quality population-based registry data of fetal and infant death.SettingFive maternity units in the North of England.Participants40 932 singleton pregnancies delivered between 2003 and 2005, excluding 1092 pregnancies associated with a congenital anomaly and/or maternal pre-gestational diabetes, and 9998 pregnancies with missing maternal body mass index (BMI).Main Outcome MeasuresPrevalence, among singleton pregnancies, of late miscarriage (20–23 weeks gestation), termination of pregnancy for fetal anomaly (≥20 weeks gestation), stillbirth (≥24 weeks gestation), fetal death (miscarriage or antepartum stillbirth), perinatal mortality, neonatal mortality, post-neonatal mortality, and all infant mortality. Crude and adjusted (for maternal age, gestational age, where appropriate, birth weight, standardised for sex and gestational age, ethnicity, cigarette smoking status, index of multiple deprivation, and sex of infant/fetus) ORs of each outcome among maternal obese (BMI ≥30 kg/m2) compared to maternal recommended BMI (BMI 18.5–24.9 kg/m2).ResultsCompared to women of recommended BMI, obese women were at significantly greater risk of a fetal death (adjusted odds ratio (aOR) 2.94 (95% CI 2.02 to 4.27), p