Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now repor...

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Bibliographic Details
Published in:Neurogenetics 1998-12, Vol.2 (1), p.55-60
Main Authors: Hentati, A, Ouahchi, K, Pericak-Vance, M A, Nijhawan, D, Ahmad, A, Yang, Y, Rimmler, J, Hung, W, Schlotter, B, Ahmed, A, Ben Hamida, M, Hentati, F, Siddique, T
Format: Article
Language:English
Subjects:
Age of Onset
Amyotrophic lateral sclerosis
Chromosome Mapping
Chromosomes, Human, Pair 15
Disease Progression
Female
Genes, Recessive
Genetic Linkage
Genetic Markers
Genetics
Humans
Male
Microsatellite Repeats
Motor Neuron Disease - genetics
Motor Neuron Disease - physiopathology
Pedigree
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Summary:Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of RFALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS. ALS5 is the locus for most families with RFALS and appears to be present in both North African and European populations.
ISSN:1364-6745
1364-6753
DOI:10.1007/s100480050052