Safety Concerns of Angiotensin II Receptor Blockers in Preschool Children

Two recent trials of angiotensin II receptor blockers (ARBs) were performed in children 0–5 years of age. Data from the published reports of these trials together with additional information from the sponsoring drug companies were obtained. Three deaths occurred in the 183 (1.6%) hypertensive childr...

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Published in:Archives of disease in childhood 2011-09, Vol.96 (9), p.881-882
Main Author: Tullus, Kjell
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Adolescents
Age
Angiotensin II receptor blockers
Angiotensin II Type 1 Receptor Blockers - adverse effects
Angiotensin Receptor Antagonists - adverse effects
Antihypertensive Agents - adverse effects
Benzimidazoles - adverse effects
Biological and medical sciences
Blood pressure
Child, Preschool
Children & youth
Clinical Trials as Topic
Dehydration
Diarrhea
Dosage and administration
Drug therapy
Drugs
Edema
Fatalities
Female
Gastroenteritis
Gastroenteritis - complications
General aspects
Humans
Hypertension
Infant
Kidneys
Male
Medical sciences
Miscellaneous
Nephrotic Syndrome - complications
Pharmaceutical industry
Preschool children
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Safety and security measures
Studies
Tetrazoles - adverse effects
Valine - adverse effects
Valine - analogs & derivatives
Valsartan
Virus Diseases - complications
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description Two recent trials of angiotensin II receptor blockers (ARBs) were performed in children 0–5 years of age. Data from the published reports of these trials together with additional information from the sponsoring drug companies were obtained. Three deaths occurred in the 183 (1.6%) hypertensive children participating in the two trials. At least two of these deaths occurred in children known to be susceptible to drugs acting on the renin–angiotensin system, that is, children with ongoing nephrotic syndrome and acute gastroenteritis. Clinicians who prescribe ARBs in preschool children need to be aware of the risk of drug toxicity especially in children susceptible to intravascular dehydration. Clinicians should consider discontinuing the drugs in the presence of acute diarrhoea.
doi_str_mv 10.1136/archdischild-2011-300172
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subjects Acute Kidney Injury - etiology
Adolescents
Age
Angiotensin II receptor blockers
Angiotensin II Type 1 Receptor Blockers - adverse effects
Angiotensin Receptor Antagonists - adverse effects
Antihypertensive Agents - adverse effects
Benzimidazoles - adverse effects
Biological and medical sciences
Blood pressure
Child, Preschool
Children & youth
Clinical Trials as Topic
Dehydration
Diarrhea
Dosage and administration
Drug therapy
Drugs
Edema
Fatalities
Female
Gastroenteritis
Gastroenteritis - complications
General aspects
Humans
Hypertension
Infant
Kidneys
Male
Medical sciences
Miscellaneous
Nephrotic Syndrome - complications
Pharmaceutical industry
Preschool children
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Safety and security measures
Studies
Tetrazoles - adverse effects
Valine - adverse effects
Valine - analogs & derivatives
Valsartan
Virus Diseases - complications
title Safety Concerns of Angiotensin II Receptor Blockers in Preschool Children
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