Evaluation of the genotoxicity of cadmium in gill cells of the clam Corbicula japonica using the comet assay

Cadmium-induced DNA degradation in gill cells of the clam Corbicula japonica was assessed using the comet assay (single-cell gel electrophoresis). Accumulation of highly toxic cadmium in the gill cells of bivalve is accompanied by damage to the cell genome, which is revealed as DNA migration in the...

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Bibliographic Details
Published in:Russian journal of marine biology 2010-07, Vol.36 (4), p.311-315
Main Authors: Slobodskova, V. V, Solodova, E. E, Slinko, E. N, Chelomin, V. P
Format: Article
Language:English
Subjects:
Accumulation
Biomedical and Life Sciences
Bivalvia
cadmium
comet assay
Corbicula japonica
DNA damage
Freshwater & Marine Ecology
genotoxicity
Life Sciences
Marine
Toxicology
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Summary:Cadmium-induced DNA degradation in gill cells of the clam Corbicula japonica was assessed using the comet assay (single-cell gel electrophoresis). Accumulation of highly toxic cadmium in the gill cells of bivalve is accompanied by damage to the cell genome, which is revealed as DNA migration in the comet assay. The main mechanisms of Cd effects on the integrity of the DNA structure are discussed.
ISSN:1063-0740
1608-3377
DOI:10.1134/s1063074010040103