Activated Immune Cells in Parkinson's Disease

Recently, an interaction between neurodegenerative processes and the innate and adaptive immune responses has been increasingly recognized. Activation of microglia, infiltration of peripheral T lymphocytes, and T-cell interaction with microglia may strongly affect the progression of Parkinson's...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2011-09, Vol.6 (3), p.323-329
Main Authors: Cao, Jun-Jun, Li, Kang-Sheng, Shen, Yan-Qin
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Disease Progression
Humans
Immunology
Invited Review
Microglia - immunology
Neurosciences
Parkinson Disease - immunology
Parkinson's disease
Pharmacology/Toxicology
T cell receptors
T-Lymphocyte Subsets - immunology
Virology
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Summary:Recently, an interaction between neurodegenerative processes and the innate and adaptive immune responses has been increasingly recognized. Activation of microglia, infiltration of peripheral T lymphocytes, and T-cell interaction with microglia may strongly affect the progression of Parkinson's disease (PD) both in patients and in animal models of the disease. Here, we summarize the current knowledge regarding the role of microglia in the progression of PD. The plasticity of the microglial response is also discussed in the context of PD. In addition, we also focus on the influence of several peripheral T-cell subsets on PD progression as well as on possible pathways by which they might act. This review should help increase our understanding of the effects of innate and adaptive immune cells in the pathogenesis of PD.
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-011-9280-9