Genistein induces breast cancer-associated aromatase and stimulates estrogen-dependent tumor cell growth in in vitro breast cancer model

Highlights ► Genistein supplements are commonly used by women with (a history) of breast cancer. ► Breast cancer is treated with letrozole to inhibit estrogen production by aromatase. ► We developed a biologically relevant in vitro co-culture breast cancer model. ► In this model genistein counteract...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2011-11, Vol.289 (2), p.67-73
Main Authors: van Duursen, M.B.M, Nijmeijer, S.M, de Morree, E.S, de Jong, P. Chr, van den Berg, M
Format: Article
Language:English
Subjects:
Animals
Aromatase
Aromatase - biosynthesis
Biological and medical sciences
Breast adipose fibroblast (BAF)
Breast cancer
breast neoplasms
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cell Survival - physiology
Coculture Techniques
Dogs
Emergency
Enzyme Induction - drug effects
Enzyme Induction - physiology
Estrogens - physiology
fadrozole
Female
fibroblasts
Genistein
Genistein - pharmacology
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
menopause
patients
risk
Toxicology
Tumors
unspecific monooxygenase
women
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Description
Summary:Highlights ► Genistein supplements are commonly used by women with (a history) of breast cancer. ► Breast cancer is treated with letrozole to inhibit estrogen production by aromatase. ► We developed a biologically relevant in vitro co-culture breast cancer model. ► In this model genistein counteracts inhibition of tumor cell growth via two pathways. ► We conclude that use of genistein during breast cancer treatment should be avoided.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.07.005