Intra uterine growth retardation: Association with organochlorine pesticide residue levels and oxidative stress markers

• Published in: Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-05, Vol.31 (4), p.534-539
• Main Authors: Pathak, Rahul, Mustafa, M.D., Ahmed, Tanzeel, Ahmed, Rafat. S., Tripathi, A.K., Guleria, Kiran, Banerjee, B.D.
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Biomarkers - blood; Birth weight; Case-Control Studies; Chi-Square Distribution; complications; Cord blood; Diseases of mother, fetus and pregnancy; Embryology: invertebrates and vertebrates. Teratology; Female; Fetal Blood - metabolism; Fetal Growth Retardation - blood; Fetal Growth Retardation - chemically induced; Fundamental and applied biological sciences. Psychology; Growth; Growth rate; Gynecology. Andrology. Obstetrics; Hexachlorocyclohexane; Humans; India; Infant, Low Birth Weight; Infant, Newborn; Intra uterine growth retardation; Isomers; Lindane - adverse effects; Lindane - blood; low-birth-weight; Maternal Exposure; Maternal-Fetal Exchange; Medical sciences; Neonates; Odds Ratio; Organochlorine pesticides; Oxidative stress; Oxidative Stress - drug effects; Pesticide Residues - adverse effects; Pesticide Residues - blood; Pesticides (organochlorine); Pesticides - adverse effects; Pesticides - blood; Pesticides, fertilizers and other agrochemicals toxicology; Pregnancy; Pregnancy. Fetus. Placenta; Risk Assessment; Risk Factors; Stereoisomers; Teratology. Teratogens; Toxicology; Uterus; Young Adult
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/j.reprotox.2011.02.007

Intra uterine growth retardation (IUGR) is a major complication of pregnancy, affecting ∼5% to 10% of newborns. Hexachlorocyclohexane (HCH) is an organochlorine pesticide that consists of eight stereoisomers and γ-isomer is the only isomer that possesses insecticidal activity. The aim of the present study was to analyze the OCP residues in maternal and cord blood of women and to assess the level of oxidative stress markers as well as to establish correlation with OCP levels. Fifty women delivering neonates with low birth weight (IUGR) and equal number of women delivering normal birth weight babies (control) were recruited. We have observed higher levels of γ-HCH and T-HCH and increased oxidative stress markers in IUGR subjects versus control subjects. Significant correlations were also found between HCH isomers and oxidative stress markers in IUGR subjects. In conclusion, our results suggest that higher levels of HCH isomers may be associated with IUGR and increased oxidative stress.