Cellular oncomiR orthologue in EBV oncogenesis

Abstract MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as a...

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Bibliographic Details
Published in:Computers in biology and medicine 2011-10, Vol.41 (10), p.891-898
Main Authors: Babu, Sunil G, Ponia, Sanket Singh, Kumar, Dinesh, Saxena, Sangeeta
Format: Article
Language:English
Subjects:
3′ Untranslated region (3′UTR)
Apoptosis
Base Sequence
Cancer
Cell Transformation, Viral - genetics
Computer applications
Computer Simulation
Conserved Sequence
Deoxyribonucleic acid
DNA
DNA methylation
EBV-associated gastric carcinoma (EBVaGC)
Epigenesis, Genetic
Epigenetics
Epstein-Barr virus
Epstein–Barr virus (EBV)
Genetics
Herpesvirus 4, Human - genetics
Humans
Infections
Internal Medicine
MicroRNA (miRNA)
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Genetic
Molecular Sequence Data
Oncogenes
OncomiRs (oncogenic miRNAs)
Other
Receptors, Glucocorticoid - genetics
RNA, Viral - genetics
RNA, Viral - metabolism
Sequence Alignment
Stomach Neoplasms - genetics
Stomach Neoplasms - virology
Ubiquitin-Conjugating Enzymes - genetics
Viral infections
Virally encoded miRNA (vmiRNA)
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Summary:Abstract MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein–Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant ‘seed’ sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2011.07.007