Indoor Air Pollution From Coal Combustion and the Risk of Neural Tube Defects in a Rural Population in Shanxi Province, China

The authors evaluated indoor air pollution from coal combustion (IAPCC) as a potential risk factor for neural tube defects (NTDs) in a rural population in Shanxi Province, China. The studied rural population has both high IAPCC exposure and a high prevalence of NTDs. A population-based case-control...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2011-08, Vol.174 (4), p.451-458
Main Authors: Li, Zhiwen, Zhang, Le, Ye, Rongwei, Pei, Lijun, Liu, Jianmeng, Zheng, Xiaoying, Ren, Aiguo
Format: Article
Language:English
Subjects:
Adult
Air pollution
Air Pollution, Indoor - adverse effects
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
China - epidemiology
Coal
Cooking
Diseases of the osteoarticular system
Diseases of the spine
Environment. Living conditions
Environmental Exposure - adverse effects
Epidemiology
Female
General aspects
Health risk assessment
Heating
Humans
Indoor air quality
Infant, Newborn
Logistic Models
Male
Medical sciences
Miscellaneous
Neural Tube Defects - epidemiology
Neural Tube Defects - etiology
Polycyclic aromatic hydrocarbons
Population Surveillance
Pregnancy
Prevalence
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Rural Population
Surveys and Questionnaires
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The authors evaluated indoor air pollution from coal combustion (IAPCC) as a potential risk factor for neural tube defects (NTDs) in a rural population in Shanxi Province, China. The studied rural population has both high IAPCC exposure and a high prevalence of NTDs. A population-based case-control study was used to identify 610 NTD cases and 837 normal controls between November 2002 and December 2007. Information was collected within 1 week following delivery or pregnancy termination due to prenatal NTD diagnosis. The authors derived an exposure index by integrating a series of IAPCC-related characteristics concerning dwelling and lifestyle. Compared with women with no IAPCC exposure, women with any exposure at all had a 60% increased risk of having a child with an NTD (adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.1, 2.1). An increased NTD risk was linked to both residential heating (adjusted OR = 1.7, 95% CI: 1.1, 2.4) and cooking (adjusted OR = 1.5, 95% CI: 1.1, 2.1). The risk increased with increases in the exposure index, showing a dose-response trend (P < 0.001). This is the first known study to link IAPCC to NTDs. Additional studies are needed to confirm the link between IAPCC and NTDs.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwr108