Glutathione-S-transferase M1 and T1 genes and gastric cancer: A case control study in North Indian population

Difference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer. A case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null geno...

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Bibliographic Details
Published in:Gene 2011-11, Vol.487 (2), p.166-169
Main Authors: Yadav, Deepmala, Chandra, Richa, Saxena, Rajan, Agarwal, Deepti, Agarwal, Mohit, Ghosh, Tanima, Agrawal, Deepa
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma - genetics
Case-Control Studies
Female
Gastric cancer (GC)
Gene Frequency
genes
Genetic Predisposition to Disease
Genotype
glutathione transferase
Glutathione Transferase - genetics
Glutathione-S-transferase (GST)
GSTM1
GSTT1
Humans
India
Male
Middle Aged
patients
PCR
polymerase chain reaction
Polymorphism
risk
stomach neoplasms
Stomach Neoplasms - genetics
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Summary:Difference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer. A case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null genotypes. The frequency of GSTM1 and GSTT1 null genotype was observed by carrying out multiplex PCR. There was no difference in the frequencies of the GSTM1 and GSTT1 null and the combined GSTM1 and GSTT1 null genotype between patients and control. Our data suggest that GSTM1 and GSTT1 status may not influence the risk of developing gastric cancer.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2011.07.010