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Glutathione-S-transferase M1 and T1 genes and gastric cancer: A case control study in North Indian population

Difference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer. A case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null geno...

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Published in:	Gene 2011-11, Vol.487 (2), p.166-169
Main Authors:	Yadav, Deepmala, Chandra, Richa, Saxena, Rajan, Agarwal, Deepti, Agarwal, Mohit, Ghosh, Tanima, Agrawal, Deepa
Format:	Article
Language:	English
Subjects:	Adult Aged Carcinoma - genetics Case-Control Studies Female Gastric cancer (GC) Gene Frequency genes Genetic Predisposition to Disease Genotype glutathione transferase Glutathione Transferase - genetics Glutathione-S-transferase (GST) GSTM1 GSTT1 Humans India Male Middle Aged patients PCR polymerase chain reaction Polymorphism risk stomach neoplasms Stomach Neoplasms - genetics
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creator	Yadav, Deepmala Chandra, Richa Saxena, Rajan Agarwal, Deepti Agarwal, Mohit Ghosh, Tanima Agrawal, Deepa
description	Difference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer. A case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null genotypes. The frequency of GSTM1 and GSTT1 null genotype was observed by carrying out multiplex PCR. There was no difference in the frequencies of the GSTM1 and GSTT1 null and the combined GSTM1 and GSTT1 null genotype between patients and control. Our data suggest that GSTM1 and GSTT1 status may not influence the risk of developing gastric cancer.
doi_str_mv	10.1016/j.gene.2011.07.010
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subjects	Adult Aged Carcinoma - genetics Case-Control Studies Female Gastric cancer (GC) Gene Frequency genes Genetic Predisposition to Disease Genotype glutathione transferase Glutathione Transferase - genetics Glutathione-S-transferase (GST) GSTM1 GSTT1 Humans India Male Middle Aged patients PCR polymerase chain reaction Polymorphism risk stomach neoplasms Stomach Neoplasms - genetics
title	Glutathione-S-transferase M1 and T1 genes and gastric cancer: A case control study in North Indian population
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