Profiling of regulatory microRNA transcriptomes in various biological processes: a review

A class of small, non-coding ribonucleic acids, termed microRNA (miRNA), has recently emerged as a new key player in the cellular control of gene expression. By either blocking translation or inducing target mRNA degradation, miRNA not only participates in regular biological processes within cells a...

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Bibliographic Details
Published in:Journal of applied genetics 2010-01, Vol.51 (4), p.501-507
Main Authors: Shah, A. A., Meese, E., Blin, N.
Format: Article
Language:English
Subjects:
Acids
Animal Genetics and Genomics
Biological activity
Biomedical and Life Sciences
Fertility
Gene expression
Gene regulation
Hibernation
Human Genetics
Life Sciences
Malignancy
Microbial Genetics and Genomics
MicroRNAs
miRNA
Non-coding RNA
Plant Genetics and Genomics
Review Article
Reviews
Ribonucleic acid
RNA
Transcriptomes
Translation
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Summary:A class of small, non-coding ribonucleic acids, termed microRNA (miRNA), has recently emerged as a new key player in the cellular control of gene expression. By either blocking translation or inducing target mRNA degradation, miRNA not only participates in regular biological processes within cells and tissues but is also involved in pathological processes. Many human malignancies have been linked to specific miRNA expression patterns, raising hopes for new approaches to therapy. While such human disease-related mechanisms have been widely discussed and frequently reviewed, miRNA’s general significance in animals has been less in editorial focus, despite its obvious role in basic physiological processes, e.g. neurosensory maturation, development of fertility, and hibernation. Using selected examples, this review highlights our current knowledge of miRNA’s potential and its promise as a new tool for gene regulation.
ISSN:1234-1983
2190-3883
DOI:10.1007/BF03208880