Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study

• Published in: Journal of allergy and clinical immunology 2011-10, Vol.128 (4), p.896-897.e9
• Main Authors: Lambiase, Alessandro, MD, PhD, Leonardi, Andrea, MD, Sacchetti, Marta, MD, PhD, Deligianni, Velika, MD, Sposato, Sabrina, MD, PhD, Bonini, Stefano, MD
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adolescent; Adult; Allergy and Immunology; Biological and medical sciences; Child; Conjunctivitis, Allergic - immunology; Conjunctivitis, Allergic - pathology; Conjunctivitis, Allergic - prevention & control; Cyclosporine - administration & dosage; Cyclosporine - adverse effects; Disease; Diseases of cornea, anterior segment and sclera; Double-Blind Method; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunopathology; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Male; Medical prognosis; Medical sciences; Ophthalmology; Recurrence; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Survival analysis; Time Factors
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2011.07.004

Because no significant differences were reported in airborne allergen concentrations in Italy during the study, we can exclude that environmental triggers played a major role in the results of the crossover year.\n3 2.2 ± 2.7 NS  0.025% Ket 3 ± 1.9 4.1 ± 2.4 5.1 ± 4 3 ± 1.9 2.2 ± 2.4  Oxford score 0.05% CsA 0.3 ± 1 0.5 ± 1.2 0.7 ± 1.4 0.6 ± 1.4 0.3 ± 1 NS  0.025% Ket 0.3 ± 1 0.8 ± 0.9 0.7 ± 1.2 0.5 ± 0.8 0.2 ± 0.8  Table E2 Topical 0.05% cyclosporine eye drops were significantly more effective in controlling itching, photophobia, and conjunctival hyperemia than 0.025% ketotifen fumarate eye drops CsA, Cyclosporine; Ket, ketotifen; NS, not statistically significant.