Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers

• Published in: Molecular biology reports 2011-11, Vol.38 (8), p.5211-5217
• Main Authors: Lee, Minhyeok, Lee, Yeiwon, Cho, Hyun-Jung, Hong, Jeeyoung, Kwon, Sun-Jung, Park, Chang-Gyo, Lee, Hoi-Young, Son, Ji-Woong, Kang, Jaeku
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Case-Control Studies; Cell Line, Tumor; chromosome 17; Chromosomes; Chromosomes, Human, Pair 17 - genetics; Cigarette smoking; Cluster Analysis; Comparative Genomic Hybridization; copy number; DNA Copy Number Variations - genetics; Gene Expression Regulation, Neoplastic; Gene Frequency - genetics; Genetic factors; Genetic Predisposition to Disease; genomics; Histology; Humans; Life Sciences; Lung cancer; Lung Neoplasms - genetics; Molecular biology; Morphology; Odds Ratio; Polymerase chain reaction; Real-Time Polymerase Chain Reaction; Risk Factors; RNA, Messenger - genetics; RNA, Messenger - metabolism; Smoking; Smoking - genetics
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-010-0672-3

Lung cancer is the most common cause of cancer death worldwide. Smoking is known as the strongest single factor in the development of lung cancer. However, there are inherited genetic factors that cause different responses to cigarette smoking exposure among individuals. We tried to identify these differences in heavy smokers by examining copy number variations (CNVs) between lung cancer patients and healthy controls. Analysis by array comparative genomic hybridization which was tested with 20-person training set (10 lung cancer patients, 10 healthy controls) showed 26 significant (adjusted P