Sildenafil to Facilitate Weaning From Inhaled Nitric Oxide and Mechanical Ventilation in a Patient With Severe Secondary Pulmonary Hypertension and a Patent Foramen Ovale

• Published in: Respiratory care 2011-10, Vol.56 (10), p.1611-1613
• Main Authors: ELIAS, Shlomo, SVIRI, Sigal, ORENBUCH-HARROCH, Efrat, FELLIG, Yakov, BEN-YEHUDA, Arie, FRIDLENDER, Zvi G, GILON, Dan, BAYYA, Abed
• Format: Article
• Language: English
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Artificial respiration; Biological and medical sciences; Bronchodilator Agents - administration & dosage; Care and treatment; Case studies; Comorbidity; Diagnosis; Dyspnea - etiology; Emergency and intensive respiratory care; Female; Foramen Ovale, Patent - epidemiology; Health aspects; Humans; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - epidemiology; Hypertension, Pulmonary - therapy; Intensive care medicine; Medical sciences; Nitric Oxide - administration & dosage; Phosphodiesterase 5 Inhibitors - administration & dosage; Phosphodiesterase 5 Inhibitors - therapeutic use; Piperazines - administration & dosage; Piperazines - therapeutic use; Pulmonary hypertension; Purines - administration & dosage; Purines - therapeutic use; Respiratory Insufficiency - etiology; Sarcoidosis, Pulmonary - complications; Sildenafil; Sildenafil Citrate; Sulfones - administration & dosage; Sulfones - therapeutic use; Vasodilator Agents - administration & dosage; Vasodilator Agents - therapeutic use; Ventilator Weaning - methods; Women
• ISSN: 0020-1324; 1943-3654
• DOI: 10.4187/respcare.01147

We describe the case of a woman who presented to the intensive care unit with acute respiratory failure that required mechanical ventilation. She had severe pulmonary hypertension secondary to interstitial lung disease, and her history included sarcoidosis and tuberculosis. She was dependent on inhaled nitric oxide (INO) to maintain safe arterial oxygen saturation and could not be weaned from mechanical ventilation. Echocardiography revealed a patent foramen ovale with substantial right-to-left shunt, which probably contributed to her hypoxemia. Sildenafil enabled weaning from INO and substantially reduced the flow through the patent foramen ovale. She was successfully extubated and discharged home. To our knowledge, this is the first report of weaning from INO and mechanical ventilation in a patient with both severe secondary pulmonary hypertension and a right-to-left shunt through a patent foramen ovale.