E-cadherin gene 3′-UTR C/T polymorphism in Turkish patients with nephrolithiasis

Nephrolithiasis is a complex disease and many gene polymorphisms have been associated with stone formation. In this study we aimed to investigate another possible relationship between E-cadherin gene ( CHD1 ) 3′-UTR C/T polymorphism and calcium oxalate nephrolithiasis in the Turkish population. Stud...

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Bibliographic Details
Published in:Molecular biology reports 2011-11, Vol.38 (8), p.4931-4934
Main Authors: Yilmaz, Akin, Menevse, Sevda, Onaran, Metin, Sen, Ilker, Ergun, Mehmet Ali, Camtosun, Ahmet, Kupeli, Bora, Bozkirli, Ibrahim
Format: Article
Language:English
Subjects:
3' Untranslated regions
3' Untranslated Regions - genetics
Adult
Aged
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cadherins - genetics
Calcium oxalate
E-Cadherin
Female
Gene frequency
Gene Frequency - genetics
Gene polymorphism
Genetic Predisposition to Disease
Genotype & phenotype
Histology
Humans
Kidney stones
Life Sciences
Male
Middle Aged
Molecular biology
Morphology
Nephrolithiasis
Nephrolithiasis - genetics
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population studies
Turkey
Young Adult
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Summary:Nephrolithiasis is a complex disease and many gene polymorphisms have been associated with stone formation. In this study we aimed to investigate another possible relationship between E-cadherin gene ( CHD1 ) 3′-UTR C/T polymorphism and calcium oxalate nephrolithiasis in the Turkish population. Study population was composed of 143 patients with nephrolithiasis and 158 control subjects. CHD1 3′-UTR C/T polymorphism was analysed using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique. Genotype distribution of the investigated polymorphism was not deviated from Hardy–Weinberg equilibrium (HWE) in patients and control subjects ( P  > 0.05). C allele frequency was 85.7 and 85.1% in patients and controls, respectively ( P  = 0.836). Genotype distributions of the CHD1 3′-UTR C/T polymorphism among patients were also not significantly different from those among control subjects ( P  = 0.636). Our results showed that there is no association between the CHD1 gene 3′-UTR C/T polymorphism and nephrolithiasis in our population.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-010-0635-8