Effect of vitamin E administration on histopathological changes in rat testes following torsion and detorsion

Testicular torsion is a medical emergency, especially in male neonates and adolescents. It is a common clinical outcome and a significant urological issue. From the literature, it is evident that the use of antioxidants in the prevention of testicular reperfusion injury following detorsion is confli...

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Bibliographic Details
Published in:Singapore medical journal 2011-10, Vol.52 (10), p.742-746
Main Authors: RANADE, A. V, TRIPATHI, Y, RAJALAKSHMI, R, VINODINI, N. A, SOUBHAGYA, R. N, NAYANATARA, A. K, REKHA, D. K, KUMARI, M
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Biopsy, Needle
Disease Models, Animal
General aspects
Gynecology. Andrology. Obstetrics
Immunohistochemistry
Male
Male genital diseases
Medical sciences
Non tumoral diseases
Random Allocation
Rats
Rats, Wistar
Reference Values
Reperfusion Injury - prevention & control
Spermatic Cord Torsion - drug therapy
Spermatic Cord Torsion - pathology
Testis - drug effects
Testis - pathology
Treatment Outcome
Vitamin E - pharmacology
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Summary:Testicular torsion is a medical emergency, especially in male neonates and adolescents. It is a common clinical outcome and a significant urological issue. From the literature, it is evident that the use of antioxidants in the prevention of testicular reperfusion injury following detorsion is conflicting. This study was conducted to investigate the role of vitamin E in testicular reperfusion injury following detorsion. Male Wistar albino rats were divided into Groups I, II, III and IV. Only Group IV rats were pre-treated with vitamin E 100 mg/kg body weight for 30 days. Ischaemia was induced manually by rotating the rat testis to 720 degrees clockwise and counter rotating for reperfusion. The testes were fixed in Bouin's fluid and processed for histopathological examination. A significant decrease in the standard tubular diameter and epithelial height was observed in Group III rats compared to those in Groups I and II. However, the seminiferous tubules in Group IV rats showed recovery in the standard tubular diameter and epithelial height when compared with the untreated control groups. The results showed that vitamin E, when administered before torsion of the spermatic cord in rats, provided significant protection against acute testicular torsion and detorsion injury.
ISSN:0037-5675