Loading…
Coffee prevents CCl(4)-induced liver cirrhosis in the rat
Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work...
Saved in:
Published in: | Hepatology international 2011-09, Vol.5 (3), p.857-863 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | |
container_end_page | 863 |
container_issue | 3 |
container_start_page | 857 |
container_title | Hepatology international |
container_volume | 5 |
creator | Moreno, Mario G Chávez, Enrique Aldaba-Muruato, Liseth R Segovia, José Vergara, Paula Tsutsumi, Víctor Shibayama, Mineko Rivera-Espinoza, Yadira Muriel, Pablo |
description | Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.
In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks.
CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels.
Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation. |
doi_str_mv | 10.1007/s12072-010-9247-6 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_900634452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>900634452</sourcerecordid><originalsourceid>FETCH-LOGICAL-p556-66adde7fa4572f694f76319617b89fe14f645394a7658602cb2aef8244649b123</originalsourceid><addsrcrecordid>eNo1j0tLxDAURoMgzjj6A9xId-oimsftTbOU4gsG3My-pO0NE-nLpB3w36s4rs7mcD4-xq6kuJdCmIcklTCKCym4VWA4nrC1tBq5yEGu2HlKH0LkOUo8YysloQCpcc1sOXpPlE2RDjTMKSvL7hbueBjapaE268KBYtaEGPdjCikLQzbvKYtuvmCn3nWJLo_csN3z06585dv3l7fyccunnzWO6NqWjHeQG-XRgjeopUVp6sJ6kuARcm3BGcwLFKqplSNfKAAEW0ulN-zmLzvF8XOhNFd9SA11nRtoXFJlhUANkP-a10dzqXtqqymG3sWv6v-s_gaPSlIG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>900634452</pqid></control><display><type>article</type><title>Coffee prevents CCl(4)-induced liver cirrhosis in the rat</title><source>Springer Nature</source><source>PubMed Central</source><creator>Moreno, Mario G ; Chávez, Enrique ; Aldaba-Muruato, Liseth R ; Segovia, José ; Vergara, Paula ; Tsutsumi, Víctor ; Shibayama, Mineko ; Rivera-Espinoza, Yadira ; Muriel, Pablo</creator><creatorcontrib>Moreno, Mario G ; Chávez, Enrique ; Aldaba-Muruato, Liseth R ; Segovia, José ; Vergara, Paula ; Tsutsumi, Víctor ; Shibayama, Mineko ; Rivera-Espinoza, Yadira ; Muriel, Pablo</creatorcontrib><description>Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.
In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks.
CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels.
Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.</description><identifier>EISSN: 1936-0541</identifier><identifier>DOI: 10.1007/s12072-010-9247-6</identifier><identifier>PMID: 21484136</identifier><language>eng</language><publisher>United States</publisher><ispartof>Hepatology international, 2011-09, Vol.5 (3), p.857-863</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21484136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno, Mario G</creatorcontrib><creatorcontrib>Chávez, Enrique</creatorcontrib><creatorcontrib>Aldaba-Muruato, Liseth R</creatorcontrib><creatorcontrib>Segovia, José</creatorcontrib><creatorcontrib>Vergara, Paula</creatorcontrib><creatorcontrib>Tsutsumi, Víctor</creatorcontrib><creatorcontrib>Shibayama, Mineko</creatorcontrib><creatorcontrib>Rivera-Espinoza, Yadira</creatorcontrib><creatorcontrib>Muriel, Pablo</creatorcontrib><title>Coffee prevents CCl(4)-induced liver cirrhosis in the rat</title><title>Hepatology international</title><addtitle>Hepatol Int</addtitle><description>Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.
In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks.
CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels.
Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.</description><issn>1936-0541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo1j0tLxDAURoMgzjj6A9xId-oimsftTbOU4gsG3My-pO0NE-nLpB3w36s4rs7mcD4-xq6kuJdCmIcklTCKCym4VWA4nrC1tBq5yEGu2HlKH0LkOUo8YysloQCpcc1sOXpPlE2RDjTMKSvL7hbueBjapaE268KBYtaEGPdjCikLQzbvKYtuvmCn3nWJLo_csN3z06585dv3l7fyccunnzWO6NqWjHeQG-XRgjeopUVp6sJ6kuARcm3BGcwLFKqplSNfKAAEW0ulN-zmLzvF8XOhNFd9SA11nRtoXFJlhUANkP-a10dzqXtqqymG3sWv6v-s_gaPSlIG</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Moreno, Mario G</creator><creator>Chávez, Enrique</creator><creator>Aldaba-Muruato, Liseth R</creator><creator>Segovia, José</creator><creator>Vergara, Paula</creator><creator>Tsutsumi, Víctor</creator><creator>Shibayama, Mineko</creator><creator>Rivera-Espinoza, Yadira</creator><creator>Muriel, Pablo</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Coffee prevents CCl(4)-induced liver cirrhosis in the rat</title><author>Moreno, Mario G ; Chávez, Enrique ; Aldaba-Muruato, Liseth R ; Segovia, José ; Vergara, Paula ; Tsutsumi, Víctor ; Shibayama, Mineko ; Rivera-Espinoza, Yadira ; Muriel, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p556-66adde7fa4572f694f76319617b89fe14f645394a7658602cb2aef8244649b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno, Mario G</creatorcontrib><creatorcontrib>Chávez, Enrique</creatorcontrib><creatorcontrib>Aldaba-Muruato, Liseth R</creatorcontrib><creatorcontrib>Segovia, José</creatorcontrib><creatorcontrib>Vergara, Paula</creatorcontrib><creatorcontrib>Tsutsumi, Víctor</creatorcontrib><creatorcontrib>Shibayama, Mineko</creatorcontrib><creatorcontrib>Rivera-Espinoza, Yadira</creatorcontrib><creatorcontrib>Muriel, Pablo</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno, Mario G</au><au>Chávez, Enrique</au><au>Aldaba-Muruato, Liseth R</au><au>Segovia, José</au><au>Vergara, Paula</au><au>Tsutsumi, Víctor</au><au>Shibayama, Mineko</au><au>Rivera-Espinoza, Yadira</au><au>Muriel, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coffee prevents CCl(4)-induced liver cirrhosis in the rat</atitle><jtitle>Hepatology international</jtitle><addtitle>Hepatol Int</addtitle><date>2011-09</date><risdate>2011</risdate><volume>5</volume><issue>3</issue><spage>857</spage><epage>863</epage><pages>857-863</pages><eissn>1936-0541</eissn><abstract>Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.
In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks.
CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels.
Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.</abstract><cop>United States</cop><pmid>21484136</pmid><doi>10.1007/s12072-010-9247-6</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | EISSN: 1936-0541 |
ispartof | Hepatology international, 2011-09, Vol.5 (3), p.857-863 |
issn | 1936-0541 |
language | eng |
recordid | cdi_proquest_miscellaneous_900634452 |
source | Springer Nature; PubMed Central |
title | Coffee prevents CCl(4)-induced liver cirrhosis in the rat |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A59%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coffee%20prevents%20CCl(4)-induced%20liver%20cirrhosis%20in%20the%20rat&rft.jtitle=Hepatology%20international&rft.au=Moreno,%20Mario%20G&rft.date=2011-09&rft.volume=5&rft.issue=3&rft.spage=857&rft.epage=863&rft.pages=857-863&rft.eissn=1936-0541&rft_id=info:doi/10.1007/s12072-010-9247-6&rft_dat=%3Cproquest_pubme%3E900634452%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p556-66adde7fa4572f694f76319617b89fe14f645394a7658602cb2aef8244649b123%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=900634452&rft_id=info:pmid/21484136&rfr_iscdi=true |