Protective effect of sodium aescinate on lung injury induced by methyl parathion

Methyl parathion (MP) is a high venenosus insecticide. It has been used in pest control of agriculture for several years. The present study is performed to investigate the protective effect of sodium aescinate (SA) on lung injury induced by MP. Forty male Sprague-Dawley rats are randomly divided int...

Full description

Saved in:
Bibliographic Details
Published in:Human & experimental toxicology 2011-10, Vol.30 (10), p.1584-1591
Main Authors: Du, Yuan, Wang, Tian, Jiang, Na, Ren, Ru-Tong, Zhao, De-Lu, Li, Chong, Fu, Feng-Hua
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biological and medical sciences
Cholinesterase Inhibitors - toxicity
Drugs, Chinese Herbal - pharmacology
Escin - chemistry
Escin - pharmacology
Glutathione - metabolism
Injuries
Insecticides
Insecticides - toxicity
Lung Injury - blood
Lung Injury - drug therapy
Lung Injury - pathology
Lungs
Male
Medical sciences
Methyl Parathion - toxicity
Nitric Oxide - metabolism
Oxidoreductases - metabolism
Pesticides, fertilizers and other agrochemicals toxicology
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Rodents
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methyl parathion (MP) is a high venenosus insecticide. It has been used in pest control of agriculture for several years. The present study is performed to investigate the protective effect of sodium aescinate (SA) on lung injury induced by MP. Forty male Sprague-Dawley rats are randomly divided into five groups, with 8 animals in each group: control group, MP administration group, MP plus SA at doses of 0.45 mg/kg, 0.9 mg/kg and 1.8 mg/kg groups. Acetylcholinesterase (AChE) activity and nitric oxide (NO) level in plasma, myeloperoxidase (MPO) activity, NO level, and antioxidative parameters in lung tissue are assayed. Histopathological examination of lung is also performed. The results show that SA has no effect on AChE. Treatment with SA decreases the activity of MPO in lung and the level of NO in plasma and lung. The level of malondialdehyde in lung is decreased after SA treatments. SA increases the activities of superoxide dismutase, glutathione peroxidase and the content of glutathione in lung. SA administration also ameliorates lung injury induced by MP. The findings indicate that SA could protect lung injury induced by MP and the mechanism of action is related to the anti-inflammatory and anti-oxidative effect of SA.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327110393764