Serum lipids level assessed in early pregnancy and risk of pre-eclampsia

Aim:  The purpose of this study investigated the relationship between early pregnancy plasma lipid concentrations and risk of pre‐eclampsia. Material and Methods:  In a prospective cohort study, maternal blood samples were collected between 10–20 weeks of gestation. From the cohort, we selected 30 w...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2011-10, Vol.37 (10), p.1427-1432
Main Authors: Demirci, Oya, Tuğrul, Ahmet Semih, Dolgun, Nihal, Sözen, Hamdullah, Eren, Sadiye
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
dyslipidemia
Female
Humans
hypertriglyceridemia
Hypertriglyceridemia - blood
Hypertriglyceridemia - complications
Lipids - blood
pre-eclampsia
Pre-Eclampsia - blood
Pre-Eclampsia - etiology
Pregnancy
Pregnancy Trimester, First - blood
Pregnancy Trimester, Second
Prospective Studies
Risk
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Summary:Aim:  The purpose of this study investigated the relationship between early pregnancy plasma lipid concentrations and risk of pre‐eclampsia. Material and Methods:  In a prospective cohort study, maternal blood samples were collected between 10–20 weeks of gestation. From the cohort, we selected 30 women who developed pre‐eclampsia and 320 who remained normotensive and served as control subjects. Linear logistic regression test was used for confounding factors identification. Results:  Women who subsequently developed pre‐eclampsia had higher concentrations of fasting plasma, total cholesterol and triglycerides than in those remaining normotensive group. After using linear logistic regression analyses for the potential confounding factors, triglyceride concentrations were significantly higher in pre‐eclamptic cases as compared with control. Conclusion:  Early pregnancy dyslipidemia, particularly hypertriglyceridemia appears associated with increased risk of pre‐eclampsia.
ISSN:1341-8076
1447-0756
DOI:10.1111/j.1447-0756.2011.01562.x