TCR diversity and Treg cells, sometimes more is more

Treg cells are critical for the maintenance of immune homeostasis and suppression of naturally occurring self‐reactive T cells; however, in order to induce suppression Treg cells must first be activated via their T‐cell receptor by recognition of specific antigen–MHC complexes. In this issue of the...

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Bibliographic Details
Published in:European journal of immunology 2011-11, Vol.41 (11), p.3097-3100
Main Authors: Wing, James B., Sakaguchi, Shimon
Format: Article
Language:English
Subjects:
Animals
Autoimmunity
Humans
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - immunology
Regulatory T cells
T-Lymphocytes, Regulatory - immunology
TCR
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Summary:Treg cells are critical for the maintenance of immune homeostasis and suppression of naturally occurring self‐reactive T cells; however, in order to induce suppression Treg cells must first be activated via their T‐cell receptor by recognition of specific antigen–MHC complexes. In this issue of the European Journal of Immunology, Föhse et al. [Eur. J. Immunol. 2011. 41: 3101–3113.] shed light on the important question of the role of TCR diversity on Treg‐cell function by demonstrating that high TCR diversity is crucial for optimal Treg‐cell expansion, peripheral reshaping of the Treg‐cell TCR repertoire and in vivo suppressive capacity. In this Commentary, we discuss these findings and also propose a simple mathematical model to aid in the understanding of the relationship between Treg‐cell TCR diversity and the level of suppression delivered by Treg cells in vivo.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201142115