Triterpenoids with Rare Carbon Skeletons from Salvia hydrangea: Antiprotozoal Activity and Absolute Configurations

Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea. The absolute configuration was determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. In v...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2011-10, Vol.74 (10), p.2200-2205
Main Authors: Moridi Farimani, M, Bahadori, M. Babak, Taheri, Salman, Ebrahimi, Samad N, Zimmermann, Stefanie, Brun, Reto, Amin, Gholamreza, Hamburger, Matthias
Format: Article
Language:English
Subjects:
Animals
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Biological and medical sciences
General pharmacology
Hydrangea
Inhibitory Concentration 50
Iran
Medical sciences
Molecular Structure
Myoblasts - drug effects
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
Rats
Salvia
Salvia - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Trypanosoma brucei rhodesiense
Trypanosoma brucei rhodesiense - drug effects
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Summary:Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea. The absolute configuration was determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. In vitro activity against Plasmodium falciparum K1 strain, Trypanosoma brucei rhodesiense STIB 900 strain, and cytotoxicity in rat myoblast (L6) cells were determined. Compounds 1 and 2 showed in vitro antiplasmodial activity, with IC50 values of 1.43 and 0.18 μM and selectivity indices (SI) of 86.2 and 69.6, respectively. IC50 values against T. brucei rhodesiense were found to be 4.33 and 15.92 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np200559c