Tirucallane-Type Triterpenoids from Dysoxylum lenticellatum

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2011-10, Vol.74 (10), p.2235-2242
• Main Authors: Huang, Hong-Li, Wang, Chun-Ming, Wang, Zhen-Hua, Yao, Ming-Jun, Han, Guang-Tian, Yuan, Ji-Cheng, Gao, Kun, Yuan, Cheng-Shan
• Format: Article
• Language: English
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Aorta - drug effects; Biological and medical sciences; Cardiovascular system; Crystallography, X-Ray; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; General pharmacology; Medical sciences; Meliaceae - chemistry; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Stems - chemistry; Rats; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Vasodilator Agents - chemistry; Vasodilator Agents - isolation & purification; Vasodilator Agents - pharmacology; Vasodilator agents. Cerebral vasodilators
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np2006296

Ten new tirucallane-type triterpenoids, represented by a rearranged skeleton dysolenticin A (1), dysolenticin B (2), a rare trinortriterpenoid dysolenticin C (3), three tirucallane triterpenoid derivatives with a hemiketal moiety dysolenticins D–F (4–6), dysolenticins G–I (7, 9, 10), and the new alkaloid dysolenticin J (12), together with seven known analogues were isolated from the twigs and leaves of Dysoxylum lenticellatum. Their structures were elucidated by extensive spectroscopic methods, and those of compounds 1, 3, 4, 6, and 10 were confirmed by single-crystal X-ray diffraction experiments. Dysolenticin J (12) showed significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 μg/mL.