Heart failure enhances arrhythmogenesis in pulmonary veins

Summary 1. Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2. The electrical activity was recorded in LA and PV fro...

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Published in:Clinical and experimental pharmacology & physiology 2011-10, Vol.38 (10), p.666-674
Main Authors: Chang, Shih-Lin, Chen, Yao-Chang, Yeh, Yung-Hsin, Lai, Yu-Jun, Yeh, Hung-I, Lin, Cheng-I, Lin, Yung-Kuo, Lin, Yenn-Jiang, Wu, Tsu-Juey, Huang, Yi-Kung, Chen, Shih-Ann, Chen, Yi-Jen
Format: Article
Language:English
Subjects:
Animals
Atrial Fibrillation - physiopathology
Electrophysiologic Techniques, Cardiac - statistics & numerical data
Heart Atria - physiopathology
Heart Failure - physiopathology
Membrane Potentials - physiology
Microelectrodes
multi-electrode
Pulmonary Veins - physiopathology
Rabbits
remodelling
triggered activity
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Summary:Summary 1. Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2. The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing‐induced HF, using a multi‐electrode array system and conventional microelectrodes. 3. Compared with the control‐PV (n = 21), the HF‐PV (n = 13) had a higher incidence and frequency of rapid pacing‐induced spontaneous activity (85 vs 29%, P = 0.005; 3.5 ± 0.2 vs 1.7 ± 0.1 Hz, P 
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.2011.05553.x