Deep Vein Thrombosis after Bunionectomy: A Case Report of Two Genetic Mutations

Abstract Deep venous thrombosis after foot and ankle surgery is a serious complication that can have potentially life-threatening complications, such as pulmonary embolus. Genetic mutations have been reported in the published data to cause an increased risk of developing deep vein thrombosis. Two su...

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Bibliographic Details
Published in:The Journal of foot and ankle surgery 2011-11, Vol.50 (6), p.733-735
Main Authors: Peterson, Kyle S., DPM, Mendicino, Robert W., DPM, FACFAS, Catanzariti, Alan R., DPM, FACFAS, Saltrick, Karl R., DPM, FACFAS
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood and lymphatic vessels
bunion
Cardiology. Vascular system
deep vein thrombosis
Diseases of the osteoarticular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Genetic Predisposition to Disease
Hallux Valgus - diagnostic imaging
Hallux Valgus - surgery
Humans
Medical sciences
methylenetetrahydrofolate reductase
Mutation
Orthopedics
Osteotomy - adverse effects
Osteotomy - methods
plasminogen activator inhibitor
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism, Genetic
Radiography
Risk Assessment
surgery
Thrombophilia - genetics
Thrombophilia - therapy
Treatment Outcome
Venous Thrombosis - drug therapy
Venous Thrombosis - etiology
Venous Thrombosis - genetics
Warfarin - therapeutic use
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Summary:Abstract Deep venous thrombosis after foot and ankle surgery is a serious complication that can have potentially life-threatening complications, such as pulmonary embolus. Genetic mutations have been reported in the published data to cause an increased risk of developing deep vein thrombosis. Two such genetic mutations are the methylenetetrahydrofolate reductase gene variant C677T and the 4G/5G polymorphism of the plasminogen activator inhibitor gene. This case report presents a female patient who developed a postoperative deep vein thrombosis after hallux valgus reconstruction. A hypercoagulable panel revealed the 2 mentioned genetic mutations. We hope this case study will highlight the importance of ascertaining all patient risk factors and the relation to perioperative deep vein thrombosis prophylaxis.
ISSN:1067-2516
1542-2224
DOI:10.1053/j.jfas.2011.05.008