Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injury

Background. Hypophosphatemia is common in critically ill patients and has been associated with generalized muscle weakness, ventilatory failure and myocardial dysfunction. Continuous renal replacement therapy causes phosphate depletion, particularly with prolonged and intensive therapy. In a prospec...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2011-11, Vol.26 (11), p.3508-3514
Main Authors: Demirjian, Sevag, Teo, Boon Wee, Guzman, Jorge A., Heyka, Robert J., Paganini, Emil P., Fissell, William H., Schold, Jesse D., Schreiber, Martin J.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - complications
Acute Kidney Injury - mortality
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Creatinine - blood
Critical Illness - mortality
Emergency and intensive care: renal failure. Dialysis management
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypophosphatemia - epidemiology
Hypophosphatemia - etiology
Incidence
Intensive care medicine
Intensive Care Units
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Prospective Studies
Renal Dialysis - adverse effects
Renal failure
Respiratory Insufficiency - etiology
Respiratory Insufficiency - mortality
Respiratory Insufficiency - surgery
Risk Factors
Survival Rate
Tracheostomy
Treatment Outcome
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Summary:Background. Hypophosphatemia is common in critically ill patients and has been associated with generalized muscle weakness, ventilatory failure and myocardial dysfunction. Continuous renal replacement therapy causes phosphate depletion, particularly with prolonged and intensive therapy. In a prospective observational cohort of critically ill patients with acute kidney injury (AKI), we examined the incidence of hypophosphatemia during dialysis, associated risk factors and its relationship with prolonged respiratory failure and 28-day mortality. Methods. This is a single-center prospective observational study. Included in the study were 321 patients with AKI on continuous dialysis as initial treatment modality. Results. Four per cent of the patients had a phosphate level
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfr075